What is surprising: Black Americans, members of other minority groups, low-wage workers, members of LGBTQ+ communities, women, the elderly, residents of rural areas, and those lacking insurance, transportation, or help in caring for ailing family members are often unable to access these advances because of who they are — and where and how they live. There is reason for hope, however, in the form of modern-day heroes. Across the United States, researchers, clinicians, patients, advocates, community leaders, and activists are working to circumvent or eliminate obstacles to care. Closing the Cancer Gap is an ongoing initiative introducing some of these dedicated changemakers who are working to ensure that care is equitable for all.